ScRNA-seq reveals chemotherapy-induced tumor microenvironment changes in pancreatic ductal adenocarcinoma.

ABSTRACT:

Background

Challenges have arisen in finding an effective treatment for pancreatic ductal adenocarcinoma (PDAC). Poor outcomes have fueled ongoing efforts to exploit the tumor microenvironment (TME) in the treatment of PDAC; however, to date, treatment strategies have largely failed. Thus, a comprehensive and deep understanding of the PDAC TME is necessary. The purpose of the present study was to investigate chemotherapy-induced tumor microenvironment changes and to optimize the response to immunotherapy in PDAC.

Methods

We analyzed publicly available single-cell RNA sequencing (scRNA-seq) PDAC (with or without standard chemotherapy) data and performed systematic analyses to elucidate novel mechanisms and to determinate the marker expression alteration induced by the chemoth

SUBMITTER: Gao F 

PROVIDER: S-EPMC12079211 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature