Long-Term Aspirin vs Clopidogrel After Coronary Stenting by Bleeding Risk and Procedural Complexity.

ABSTRACT:

Importance

Antiplatelet monotherapy in the chronic maintenance period for patients with high bleeding risk (HBR) and those who have undergone complex percutaneous coronary intervention (PCI) has not yet been explored.

Objective

To compare clopidogrel vs aspirin monotherapy in patients with HBR and/or PCI complexity.

Design, setting, and participants

This post hoc analysis of the multicenter HOST-EXAM Extended study, an open-label trial conducted across 37 sites in South Korea, enrolled patients from 2014 to 2018 with up to 5.9 years of follow-up. The analysis was conducted from February to November 2023. Patients who maintained dual antiplatelet therapy (DAPT) event-free for 6 to 18 months following PCI were included.

Interventions

Patients were randomized to r

SUBMITTER: Kang J 

PROVIDER: S-EPMC12079284 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature