Association of Depression Dimensions With Cognitive Functioning in Community-Dwelling Oldest-Old Adults: The LifeAfter90 Study.

ABSTRACT:

Objectives

The oldest-old adults (90+) constitute the fastest-growing demographic at the highest dementia risk among older adults. Depression, a common risk factor, inherently presents with heterogeneous clinical manifestations. Here, we explored the associations of the predominant depression dimensions with cognition in the LifeAfter90 study.

Methods

The LifeAfter90 study consists of racially/ethnically diverse community-dwelling adults of >90. Cognitive assessments measured episodic memory, semantic memory, and executive function. Baseline depression was measured by the Geriatric Depression Scale-15 item (GDS-15), yielding dimensions of Dysphoria, Withdrawal-Apathy-Vigor, Anxiety, Hopelessness, and Subjective Memory Complaint (SMC). We used generalized linear mixed models

SUBMITTER: Soleimani L 

PROVIDER: S-EPMC12079382 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature