Low-Coordination Configuration Single-Atom Manganese Nanozymes for NIR-Imaging-Oriented Efficient Catalytic Oncotherapy.

ABSTRACT: Single-atom nanozymes (SAzymes) with low coordination structure has more active sites at an atomic level, which is one of the effective strategies to improve the efficiency of tumor catalytic therapy. Herein, it is reported that simple preparation of single-atom manganese-doped carbon dots (SA Mn-CDs) with low coordination (Mn-N₂) configuration formed by chelating manganese atoms with ethylenediamine tetraacetic acid (EDTA). SA Mn-CDs show good dispersibility of different solvents, excellent biological safety and stability, and show deep level (34 µm) of two-photon fluorescence imaging ability and exclusive function (Pearson's correlation coefficient: 0.752) of targeting lysosomes at the cellular level. This further promotes the high-efficiency peroxidase (POD)-like activity (SA

SUBMITTER: Jin P 

PROVIDER: S-EPMC12079523 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature