Spironolactone vs Amiloride for Resistant Hypertension: A Randomized Clinical Trial.

ABSTRACT:

Importance

Amiloride has been proposed as an alternative to spironolactone for treating resistant hypertension. However, no randomized clinical trials have compared the efficacy of spironolactone and amiloride in patients with resistant hypertension.

Objective

To determine whether amiloride is noninferior to spironolactone in reducing home-measured systolic blood pressure (SBP) in patients with resistant hypertension.

Design, setting, and participants

Prospective, open-label, blinded end-point randomized clinical trial conducted at 14 sites in South Korea. From November 16, 2020, to February 29, 2024, 118 patients with home SBP of 130 mm Hg or greater after a 4-week run-in period with a fixed-dose triple medication combination (angiotensin receptor blocker, calcium ch

SUBMITTER: Lee CJ 

PROVIDER: S-EPMC12079568 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature