Antifungal Structure-Activity Relationship Studies of Broad-Spectrum Phenothiazines.

ABSTRACT: Fungal infections remain a critical unmet medical need with millions of infections occurring annually. With only three classes of antifungal drugs available, drug resistance and modest activity toward some fungi represent threats to human health. To address this, optimization of the antifungal properties of approved drugs with appropriate pharmacokinetic properties represents an attractive strategy. Here, we have shown that the antifungal activity of phenothiazine-based CWHM-974 extends to include fluconazole-resistant Candida albicans, Candida auris, and Cryptococcus glabrata, filamentous molds such as Aspergillus fumigatus, Fusarium spp., and Rhizopus arrhizus, endemic human fungal pathogens Histoplasma capsulatum, Blastomyces de

SUBMITTER: Brosend SC 

PROVIDER: S-EPMC12079586 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature