Deciphering the Molecular Crosstalk of Endoplasmic Reticulum Stress and Immune Infiltration in Endometriosis.

ABSTRACT:

Background

Endometriosis (EMs), characterized by ectopic endometrial growth causing infertility. Endoplasmic reticulum stress (ERS) is an important cellular defense mechanism. However, the correlation between ERS and EMs remains unclear. We aimed to investigate the relationship between them, identify biomarkers, and offer new insights into the treatment of EMs.

Methods

Two RNA expression datasets (GSE120103 and GSE25628) related to EMs in Homo sapiens were used to identify ERS-differentially expressed genes (ERS-DEGs). Protein-protein interaction (PPI) networks and CytoHubba (Cytoscape) identified ERS-associated HUB genes, with receiver operating characteristic curves (ROC) evaluating diagnostic value. Constructed mRNA-microRNA (miRNA)/RNA-transcription factor (TF) interacti

SUBMITTER: Ma Y 

PROVIDER: S-EPMC12079719 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature