A Role for δ Subunit-Containing GABA_A Receptors on Parvalbumin-Positive Neurons in Maintaining Electrocortical Signatures of Sleep States.

ABSTRACT: GABA_A receptors containing δ subunits have been shown to mediate tonic/slow inhibition in the CNS. These receptors are typically found extrasynaptically and are activated by relatively low levels of ambient GABA in the extracellular space. In the mouse neocortex, δ subunits are expressed by some pyramidal cells as well as on parvalbumin-positive (PV+) interneurons. An important function of PV+ interneurons is the organization of coordinated network activity that can be measured by EEG. However, it remains unclear what role tonic/slow inhibitory control of PV+ neurons may play in shaping oscillatory activity. After validating expected functional loss of δ-associated current in cortex of PV δcKO mice of both sexes, we performed EEG recordings to survey network activity across wake

SUBMITTER: Lambert PM 

PROVIDER: S-EPMC12079746 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature