Genetic characterization and pathogenicity of two recombinant PRRSV-2 strains from lineages 1, 3, 5, and 8 emerged in China.

ABSTRACT:

Background

Porcine reproductive and respiratory syndrome virus (PRRSV) is a major economic threat to the global swine industry. Currently, NADC30-like PRRSV has undergone complex recombination with local Chinese strains, which has exacerbated the evolution of PRRSV. Recently, new recombinant PRRSV-2 strains from four lineages (lineages 1, 3, 5, and 8) have emerged in China. However, information on the pathogenicity of the novel isolate in China remains limited. To further our knowledge about the isolate, FJLIUY2017 and PRRSV2/CN/G8/2018 were selected to analyze their pathogenicity for piglets.

Methods

The PRRSV FJLIUY2017 and PRRSV2/CN/G8/2018 strains were isolated by porcine alveolar macrophages (PAMs) and MARC-145CD¹⁶³. Complete genomic sequence analyses were co

SUBMITTER: Wei C 

PROVIDER: S-EPMC12079828 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature