Gastrin-releasing peptide is essential for generalization of auditory conditioned fear under stress.

ABSTRACT: Fear generalization, which allows animals to respond adaptively to cues similar to original threatening ones, is generally beneficial for survival. However, an inability to distinguish between threat and safety, leading to the overgeneralization of fear to non-threatening stimuli, is maladaptive and is implicated in anxiety disorders such as post-traumatic stress disorder (PTSD). The neuropeptide gastrin-releasing peptide (GRP) is known to modulate fear memory under stress, yet its role in response to intense aversive stimuli remains less understood. In this study, we used GRP knockout (Grp^-/-) mice to examine the role of GRP in enhancing fear responses to conditioned stimulus (10 kHz tone, CS+) and non-conditioned stimulus (2 kHz tone, CS-) in a model of auditory fear condition

SUBMITTER: Wu Y 

PROVIDER: S-EPMC12080023 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature