Transcriptomic signatures of oxytosis/ferroptosis are enriched in Alzheimer's disease.

ABSTRACT:

Background

Oxytosis/ferroptosis is a form of non-apoptotic regulated cell death characterized by specific changes in the redox balance that lead to lethal lipid peroxidation. It has been hypothesized recently that aging predisposes the brain to the activation of oxytosis/ferroptosis in Alzheimer's disease (AD), and consequently that inhibition of oxytosis/ferroptosis offers a path to develop a new class of therapeutics for the disease. The goal of the present study was to investigate the occurrence of oxytosis/ferroptosis in the AD brain by examining transcriptomic signatures of oxytosis/ferroptosis in cellular and animal models of AD as well as in human AD brain samples.

Results

Since oxytosis/ferroptosis has been poorly defined at the RNA level, the publicly available data

SUBMITTER: Currais A 

PROVIDER: S-EPMC12080116 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature