A near telomere-to-telomere genome assembly of the Jinhua pig: enabling more accurate genetic research.

ABSTRACT:

Background

Pigs are crucial sources of meat and protein, valuable animal models, and potential donors for xenotransplantation. However, the existing reference genome for pigs is incomplete, with thousands of segments and centromeres and telomeres missing, which limits our understanding of the important traits in these genomic regions.

Findings

We present a near-complete genome assembly for the Jinhua pig (JH-T2T) and provide a set of diploid Jinhua reference genomes, constructed using PacBio HiFi, ONT long reads, and Hi-C reads. This assembly includes all 18 autosomes and the X and Y sex chromosomes, with only 6 gaps. It features annotations of 46.90% repetitive sequences, 33 telomeres, 17 centromeres, and 23,924 high-confident genes. Compared to the Sscrofa11.1, JH-T2T clos

SUBMITTER: Cao C 

PROVIDER: S-EPMC12080228 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature