A Cytotoxic Indazole-based Gold(III) Carboxamide Pincer Complex Targeting DNA Through Dual Binding Modes of Groove Binding and Alkylation.

ABSTRACT: Gold(III) complexes have garnered increasing attention in drug delivery due to their structural and mechanistic similarities to cisplatin. This study investigates an indazole-based gold(III) carboxamide pincer complex, [N²·N⁶-bis(1-methyl-¹H-indazol-3-yl)pyridine-2·6-dicarboxamide]gold(III) chloride (AuL), for its potential as an anticancer agent. Speciation analysis at physiological pH revealed that AuL predominantly exists as a neutral chlorinated species. The complex exhibited strong cytotoxicity against the MCF-7 breast cancer cell line, with an impressive IC₅₀ value of 9 µM, while showing no significant activity against the HT-29 colon cancer cell line. Comprehensive analysis using electrophoresis, viscometry, ultraviolet-visible spectroscop

SUBMITTER: Razuwika R 

PROVIDER: S-EPMC12080311 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature