Skeletal stem/progenitor cell-derived rather than osteoblast-derived IGF2 supports the development and homeostasis of skeletal system via STAT3.

ABSTRACT: Rationale: Skeletal deformities are characteristic manifestations of Silver-Russell Syndrome with mutations in insulin-like growth factor 2 (IGF2) gene serving as the most prevalent genetic abnormality. However, the mechanism by which IGF2 influence bone development and homeostasis remains unclear. Besides, the expression pattern of Igf2 and the local cells-derived Igf2 at cellular level within bone microenvironment also lacked research. Methods: ScRNA-seq analysis was obtained from Gene Expression Omnibus (GEO) and analyzed to discover the expression pattern of Igf2. Then, mice models of specific deletion of Igf2 in three different cell types by crossing Igf2 flox with Osx^cre , Prx1^cre and <

SUBMITTER: Wang T 

PROVIDER: S-EPMC12080382 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature