Randomized controlled trial of zolpidem as a pharmacotherapy for cannabis use disorder.

ABSTRACT:

Background

Sleep disturbance is commonly reported among individuals meeting criteria for cannabis use disorder (CUD), and people who use cannabis frequently report sleep disturbance as a contributor to failed quit attempts. The purpose of this study was to measure sleep in individuals enrolled in treatment for CUD, and to determine whether use of hypnotic medication during treatment increased abstinence rates.

Method

The study enrolled 127 adults seeking treatment for CUD in a 12-week clinical trial and randomized to receive extended-release zolpidem (zolpidem-XR) or placebo. All participants received computerized behavioral therapy and abstinence-based contingency management. The study conducted in-home ambulatory polysomnography (PSG) assessments at baseline and during tre

SUBMITTER: Lee DC 

PROVIDER: S-EPMC12080489 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature