The immunopeptidomic landscape of ependymomas provides actionable antigens for T-cell-based immunotherapy.

ABSTRACT:

Background

Ependymoma are primary tumors of the nervous system. Due to their growth pattern, many ependymomas can be managed with neurosurgical resection alone. A substantial proportion of these tumors recurs or displays infiltrative growth patterns. Further established therapeutic options include radiation therapy. Systemic treatment options include platinum-based therapeutic regimes or a combination of lapatinib and temozolomide. Peptide-based immunotherapy represents a promising therapeutic strategy relying on the induction of tumor-specific T cells targeting human leukocyte antigens (HLA)-presented peptides. Our work aimed to analyze the landscape of naturally presented HLA class I and II ligands of primary ependymomas (EPN) to delineate EPN-associated antigens.

Methods

SUBMITTER: Muhlenbruch L 

PROVIDER: S-EPMC12080555 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature