Screening and identification of versican as a sensitive biomarker and potential therapeutic target in basal cell carcinoma.

ABSTRACT: Basal cell carcinoma (BCC) is the most common type of non-melanoma skin cancer (NMSC). However, few biomarkers have been developed for the diagnosis of BCC. This study aimed to uncover novel BCC biomarkers for diagnosis and treatment via transcriptome and pathogenesis investigations. Microarray datasets of BCC tissues were downloaded from the Gene Expression Omnibus (GEO) database and differentially expressed genes (DEGs) were identified. A total of 558 DEGs were identified between BCC and normal samples from the GSE125285 and GSE42109 datasets. 69 DEGs were expressed in a tissue/organ-specific manner, of which three tissue-specific key genes were finally identified. The three genes showed high performance for BCC diagnosis with AUCs of ≥0.8, indicating that they have high diagnostic signi

SUBMITTER: Li W 

PROVIDER: S-EPMC12080574 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature