Altered corticostriatal connectivity in long-COVID patients is associated with cognitive impairment.

ABSTRACT:

Background

The COVID-19 pandemic has had a significant impact on the health of millions of people worldwide, and many manifest new or persistent symptoms long after the initial onset of the infection. One of the leading symptoms of long-COVID is cognitive impairment, which includes memory loss, lack of concentration, and brain fog. Understanding the nature and underlying mechanisms of cognitive impairment in long-COVID is important for developing preventive and therapeutic interventions.

Methods

Our present study investigated functional connectivity (FC) changes in patients with long-COVID and their associations with cognitive impairment. Resting-state functional MRI data from 60 long-COVID patients and 52 age- and sex-matched healthy controls were analyzed using seed-based

SUBMITTER: Troll M 

PROVIDER: S-EPMC12080633 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature