Reduction of oxytocin plasma levels in borderline personality disorder and normalization induced by psychotherapies.

ABSTRACT:

Background

Borderline personality disorder (BPD) is a severe mental disorder characterized by emotional dysregulation, impulsive behaviors, and difficulties in interpersonal relationships. Despite the poor understanding of the underlying biological processes, the oxytocin (OXT) system may be involved in and mediate some of BPD's symptomatic and behavioral aspects. To clarify OXT's role in BPD, we assessed its plasma levels and modulations induced by psychotherapies in patients.

Methods

Fifty BPD patients and 28 healthy controls (HC) participated in the study; patients were randomly assigned to two psychotherapeutic treatments: metacognitive interpersonal therapy and structured clinical management. Clinical and psychometric measures were assessed, and plasma was collected at

SUBMITTER: Bocchio Chiavetto L 

PROVIDER: S-EPMC12080657 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature