Within-subjects ultra-short sleep-wake protocol for characterising circadian variations in retinal function.

ABSTRACT: Prior studies suggest that visual functions undergo time-of-day variations. Under naturalistic entrainment, diurnal changes in physiology may be driven by circadian and/or homeostatic processes, and repeated measurements at different times of day are thus not suitable to draw unambiguous conclusions about circadian effects on visual function. In this study, we disentangle circadian and homeostatic effects on variations of retinal function. We examine the earliest stages of image-forming (temporal contrast sensitivity of the post-receptoral channels) and non-image forming visual functions (pupillary light response) by employing a short forced-desynchrony multiple-naps protocol lasting 40 hours. Participants (n = 12, 50% female) will stay in a controlled time-isolating environment under dim-

SUBMITTER: Heinrichs HS 

PROVIDER: S-EPMC12080756 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature