Microglia remodeling in the visual thalamus of the DBA/2J mouse model of glaucoma.

ABSTRACT: Microglia are the resident immune cells of the central nervous system and mediate a broad array of adaptations during disease, injury, and development. Typically, microglia morphology is understood to provide a window into their function and microglia have the capacity to adopt a broad spectrum of functional phenotypes characterized by numerous morphologies and gene expression profiles. Glaucoma, which leads to blindness from retinal ganglion cell (RGC) degeneration, is commonly associated with elevated intraocular pressure (IOP) and triggers microglia responses within the retinal layers, at the optic nerve head, and in retinal projection targets in the brain. The goal of this study was to determine the relationship of microglia morphology to intraocular pressure and the loss of RGC output

SUBMITTER: Thompson JL 

PROVIDER: S-EPMC12080812 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature