Differences in sputum microbiota based on cure status of patients with nontuberculous mycobacterial pulmonary disease.

ABSTRACT:

Background/aims

To analyze the characteristics of the sputum microbiota of patients with nontuberculous mycobacteria pulmonary disease (NTM-PD) based on treatment status.

Methods

Twenty-eight sputum samples from 14 patients with NTM-PD, including 14 samples from the microbiologically cured group (7 at baseline and 7 during follow-up) and 14 from the treatment-refractory group (7 at baseline and 7 during follow-up) were included in this study. Bacterial microbiota was analyzed by sequencing the V3-V4 region of the 16S rRNA gene.

Results

Among the 14 patients, most had infections with Mycobacterium avium complex (n = 6), followed by Mycobacterium abscessus (n = 5); three patients exhibited mixed infection with both organisms. Alpha-diversity was higher in the cured grou

SUBMITTER: Kang N 

PROVIDER: S-EPMC12081110 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature