MO Oxygen Therapy Prevents Doxorubicin-Induced Cardiotoxicity.

ABSTRACT: Background: Micro-oxygen therapy can reduce the effects of doxorubicin (DOX) on left ventricular function, cardiac fibrosis, inflammation, and oxidative stress in SD rats. These results suggest the potential of DOX for clinical use. Method: 8-week-old SPF-grade SD male rats were randomly divided into four groups: control group (Ctrl) (n = 10), doxorubicin group (DOX) (n = 10), doxorubicin + conventional oxygen intervention group (DOX+CO) (n = 10), doxorubicin + micropressed oxygen group (DOX+MO)) (n = 10). Left ventricular function was assessed by echocardiography 3 weeks after the end of treatment, and histopathological analysis was conducted utilizing Masson and hematoxylin-eosin (HE) staining. The mRNA expression levels of TGF-β1 and Collagen I

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12081151 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature