Club cell secretory protein (CC16) polymorphisms in preterm neonates with respiratory distress syndrome and bronchopulmonary dysplasia.

ABSTRACT: To investigate the genotype frequencies of club cell secretory protein (CC16) polymorphisms in preterm neonates and explore their association with respiratory distress syndrome (RDS), and bronchopulmonary dysplasia (BPD). A prospective cohort study was conducted including 187 preterm neonates of ≤ 34 weeks of gestational age. Genotype frequencies of rs4963506, rs12270961, and rs3741240 CC16 polymorphisms were detected, comparing the CC16 polymorphisms between neonates with versus without RDS, and with versus without BPD. Serum CC16 was measured, when available, on the first and fourteenth postnatal days. A significant association of increased risk of RDS was detected for the homozygous GG rs4963506 variant (OR 3.03, 95%CI 1.36-6.75, p = 0.021), and the homozygous GG rs12270961 variant (OR

SUBMITTER: Rallis D 

PROVIDER: S-EPMC12081523 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature