Splenic T2 signal intensity loss on MRI is associated with disease burden in multiple myeloma.

ABSTRACT:

Objectives

This study aims to evaluate correlations between spleen signal changes in different MRI sequences and bone marrow plasma cell infiltration as potential indicator of disease burden in multiple myeloma (MM) patients.

Materials and methods

We retrospectively analyzed 45 patients with newly diagnosed MM that underwent whole-body MRI with axial DWI at b-values 50 (b50) and 800 (b800), and coronal T1 and T2 fast spin-echo (T2-TSE) imaging. A subcohort of 39 patients had concomitant [¹⁸F]FDG PET/CT. The spleen was segmented in all MRI sequences and signal intensities were normalized. MR signal intensities and ADC values were correlated with bone marrow plasma cell infiltration from biopsy, laboratory markers (Beta 2-microglobulin, M-Protein, Red blood count (R

SUBMITTER: Neelsen C 

PROVIDER: S-EPMC12081551 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature