Chemotactic Zn micromotor for treatment of high blood ammonia-associated hepatic encephalopathy.

ABSTRACT: Hepatic fibrosis involves hepatocyte damage, causing blood ammonia accumulation, which exacerbates liver pathology and crosses the blood-brain barrier, inducing hepatic encephalopathy. It is meaningful to construct a therapeutic platform for targeted ammonia clearance. In this work, a biocompatible water-powered Zn micromotor is constructed as an ammonia chemotaxis platform, which can be actuated by the water splitting reaction and the self-generated Zn²⁺ gradient. It can propel towards NH₃·H₂O source through the formation of complex ions [Zn(NH₃)₁](OH)⁺ and [Zn(NH₃)₂](OH)⁺, representing a generalizable chemotaxis strategy via coordination reaction. In vivo, biomimetic collective behavior all

SUBMITTER: Feng Y 

PROVIDER: S-EPMC12081644 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature