Assessing the risk of second primary lung cancer in women after previous breast cancer.

ABSTRACT:

Background

Breast cancer (BC) survivors may be at increased risk of developing second cancers compared to those without BC diagnosis due to shared risk factors and potential carcinogenic effects of cancer therapy. Lung cancer (LC) is the most common second primary cancer among BC survivors. This study aimed to evaluate the association between BC and the subsequent incidence of LC.

Methods

Women aged 55-74 were identified from the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. The risk of incident LC was compared by BC status using a multivariable Cox regression model with BC and smoking exposures incorporated as time-updated variables.

Results

75,951 females from the PLCO trial were identified, with 5808 diagnosed with BC after enrollment. The

SUBMITTER: Huang Y 

PROVIDER: S-EPMC12081664 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature