ITGAV, a specific biomarker associated with the pathogenesis of idiopathic pulmonary fibrosis.

ABSTRACT: Objective Idiopathic pulmonary fibrosis (IPF), which radiologically/pathologically manifests mainly as usual interstitial pneumonia (UIP), is easily confused with chronic hypersensitivity pneumonitis (CHP) and collagenous vascular disease in clinical settings, affecting the physician's diagnosis and treatment. Accurate identification of IPF from various diseases presenting as UIP is essential for effective diagnosis and therapy. Methods Gene expression data of CHP, IPF, and rheumatoid arthritis-UIP samples were downloaded from the GEO database, and specific biomarkers were identified to differentiate idiopathic UIP/IPF from secondary UIP. We compared gene expression of specific biomarkers between control, secondary UIP, and IPF groups. The mechanism of specific biomarkers in PF was explore

SUBMITTER: Bi Z 

PROVIDER: S-EPMC12081863 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature