A novel, covalent broad-spectrum inhibitor targeting human coronavirus M^pro.

ABSTRACT: Human coronaviruses (CoV) cause respiratory infections that range from mild to severe. CoVs are a large family of viruses with considerable genetic heterogeneity and a multitude of viral types, making preventing and treating these viruses difficult. Comprehensive treatments that inhibit CoV infections fulfill a pressing medical need and may be immensely valuable in managing emerging and endemic CoV infections. As the main protease (M^pro) is highly conserved across many CoVs, this protease has been identified as a route for broad CoV inhibition. We utilize the advanced generative chemistry platform Chemistry42 for de novo molecular design and obtained novel small-molecule, non-peptide-like inhibitors targeting the SARS-CoV-2 M^pro. ISM3312 is identified as an irreversib

SUBMITTER: Sun J 

PROVIDER: S-EPMC12081877 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature