Brain Metabolic Features of FUS-ALS: A 2-[¹⁸F]FDG-PET Study.

ABSTRACT:

Objective

We aimed at evaluating the brain metabolic features of fused in sarcoma amyotrophic lateral sclerosis (FUS-ALS) compared with sporadic ALS (sALS), using 2-[fluorine-18] fluoro-2-deoxy-D-glucose positron emission tomography (2-[¹⁸F]FDG-PET).

Methods

We employed the 2-sample t-test model of SPM12, implemented in MATLAB, to compare 12 FUS-ALS cases with 40 healthy controls (HC) and 48 sALS, randomly collected from the series of patients who underwent brain 2-[¹⁸F]FDG-PET at the ALS Center of Turin (Italy) at diagnosis from 2009 to 2019. In the comparisons between cases and HC, we included age at PET and sex as covariates. Because FUS-ALS usually shows early onset in spinal regions, in the comparison between FUS-ALS and sALS, we included singularl

SUBMITTER: Canosa A 

PROVIDER: S-EPMC12081991 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature