Exploring Mobile Genetic Elements in Vibrio cholerae.

ABSTRACT: Members of the bacterial species Vibrio cholerae are known both as prominent constituents of marine environments and as the causative agents of cholera, a severe diarrheal disease. While strains responsible for cholera have been extensively studied over the past century, less is known about their environmental counterparts, despite their contributions to the species' pangenome. This study analyzed the genome compositions of 46 V. cholerae strains, including pandemic and nonpandemic, toxigenic, and environmental variants, to investigate the diversity of mobile genetic elements (MGEs), embedded bacterial defense systems, and phage-associated signatures. Our findings include both conserved and novel MGEs across strains, pointing to shared evolutionary pathways and ecological niches. The defen

SUBMITTER: Drebes Dorr NC 

PROVIDER: S-EPMC12082036 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature