Using human genetics to understand the epidemiological association between neuroticism and lung cancer.

ABSTRACT:

Background

Neuroticism, a personality trait characterized by emotional instability, has been linked to an increased risk of lung cancer (LC). However, the genetic underpinnings of this association remain poorly understood. This study aimed to comprehensively dissect the genetic link underlying neuroticism and LC.

Methods

We used genome-wide association study (GWAS) data to investigate the intricate genetic relationship between neuroticism and LC, along with specific histological subtypes: lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), and small-cell LC (SCLC). Our analytical framework encompassed global and local genetic correlation, cross-trait meta-analysis, transcriptome-wide association study (TWAS), and bidirectional Mendelian randomization (MR) analys

SUBMITTER: Wu D 

PROVIDER: S-EPMC12082198 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature