DNA damage and repair (DDR) gene mutation profiles in driver gene wild-type advanced non-small cell lung cancer and the predictive role of response to platinum-based chemotherapy.

ABSTRACT:

Background

Platinum-based chemotherapy is an important therapeutic approach for patients with advanced non-small cell lung cancer (NSCLC) without driver gene mutations. DNA damage and repair (DDR) gene can mitigate platinum-induced DNA damage and induce resistance to platinum agents. The status of DDR gene in advanced driver gene wild-type NSCLC and their role in determining response and prognosis to platinum-based chemotherapy need to be investigated. This study used next-generation sequencing (NGS) to detect the mutation status of 47 DDR genes in seven DDR signaling pathways in driver gene wild-type NSCLC patients and to investigate their association with cisplatin-based chemotherapy.

Methods

From November 2016 to September 2021, 182 cases of treatment-naïve patients with

SUBMITTER: Wu T 

PROVIDER: S-EPMC12082227 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature