Survival outcomes of pulmonary metastasis-directed local therapy in adenoid cystic carcinoma.

ABSTRACT:

Background

Adenoid cystic carcinoma (ACC) frequently has pulmonary metastasis (PM). Given limited systemic therapy options, these metastases are often treated with pulmonary metastasis-directed local therapy (PM-LT), although with unknown impact on overall survival (OS). This single institution, retrospective cohort study investigated the survival outcomes of PM-LT versus no PM-LT in ACC.

Methods

ACC patients with at least one PM (≥5 mm) were included. PM-LT was metastasectomy or radiotherapy. Clinicopathologic characteristics were compared between patients with and without PM-LT. Primary end point was OS from PM diagnosis, with landmark analysis at 6 months, 1 year, 2 years, and 3 years after metastasis diagnosis, with Cox proportional hazards model multivariate analysis an

SUBMITTER: Hoff CO 

PROVIDER: S-EPMC12082800 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature