Novel exosome-associated LncRNA model predicts colorectal cancer prognosis and drug response.

ABSTRACT:

Background

Exosomes are extracellular vesicles that carry various biological substances and have potential as functional mediators in cancers. However, little is known about special molecules in colorectal cancer (CRC) exosomes and their immunological functions.

Aims

Using genomic data from the TCGA-CRC cohort, we constructed a prognostic model based on exosome-related lncRNA for the first time, and the biological role of MIR4713HG in CRC was deeply analyzed.

Method

In this study, we downloaded the gene expression data and clinical data of CRC from the TCGA database. The limma package, SVM-REF and univariate Cox analysis were used to screen out core ERG (CERG) in CRC. LASSO and multivariate Cox regression analyses were used to filter out CERG-related LncRNA and constr

SUBMITTER: Zhou C 

PROVIDER: S-EPMC12082951 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature