Meningiomas: Sex-specific differences and prognostic implications of a chromosome X loss.

ABSTRACT:

Background

Meningiomas are the most common primary intracranial tumors in adults. Several studies proposed new stratification systems with a more accurate risk prediction than the WHO grading, eg, based on methylation and copy-number variations (CNVs). Yet, common shortcomings in these analyses are either a lack of stratification by sex of patients or excluding the gonosomes from CNV assessment.

Methods

Within this study, DNA methylation array data from 7424 meningioma samples as well as targeted sequencing, clinical annotations, and morphology subtyping of 796 samples were examined for differences between females and males regarding mutations, methylation classes, CNVs, and histology.

Results

Meningiomas from females accounted for about 53% of the malignant tumors an

SUBMITTER: Berghaus N 

PROVIDER: S-EPMC12083225 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature