Intravenous acetaminophen for postoperative delirium in older patients recovering from major non-cardiac surgery: a randomised-controlled study protocol.

ABSTRACT:

Introduction

Delirium is a common complication in elderly patients after major surgeries and can lead to poor outcomes such as neurocognitive decline. Acetaminophen is one of the most widely used adjuvants for perioperative multimodal analgesia. Previous studies showed that it can effectively alleviate postoperative pain, promote opioid sparing and exert anti-neuroinflammatory response, showing strong potential for preventing postoperative delirium. We, thus, propose to test the primary hypothesis that postoperative intravenous acetaminophen would reduce delirium over 5 postoperative days in older patients following major non-cardiac surgery.

Methods and analysis

We propose a multicentre, randomised, placebo-controlled, parallel-group trial in patients aged>65 years old sche

SUBMITTER: Zheng M 

PROVIDER: S-EPMC12083319 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature