One-week regimen for postoperative regional irradiation in breast cancer: the ARROW trial protocol.

ABSTRACT:

Introduction

Shortening the duration of postoperative radiotherapy (RT) for breast cancer while maintaining efficacy and safety has become a significant trend. The 3-week regimen of 40-42.5 Gy in 15-16 fractions is now a preferred option in clinical practice. Following the publication of the 5-year outcomes from the Fast-Forward trial, interest in 1-week regimens has surged, prompting the initiation of multiple studies. However, trials exploring the 1-week regimen for regional nodal irradiation (RNI), especially involving internal mammary nodes (IMN), remain scarce. Additionally, the optimal fractionation scheme for tumour bed boost in the era of ultra-hypofractionated regimens is still debated. To address these gaps, we initiated the adjuvant regional nodal radiation therapy for o

SUBMITTER: Xie J 

PROVIDER: S-EPMC12083394 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature