Humoral SARS-CoV-2 vaccine responses are durable in solid organ transplant recipients with and without HIV.

ABSTRACT:

Background

Solid organ transplant (SOT) recipients may have a suboptimal humoral immune response to the coronavirus disease 2019 (COVID-19) vaccine, prompting the need for additional doses of vaccine for immunocompromised patients. However, data regarding immune responses to vaccination specifically in SOT recipients with well controlled HIV are lacking.

Methods

We conducted a prospective observational cohort single-center study of SOT recipients with and without HIV-1 who had received two doses of mRNA COVID-19 vaccine and were planning to receive additional doses. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binding and neutralizing antibody responses were measured at several time points after vaccination.

Findings

Of the 122 SOT recipients enrolled,

SUBMITTER: Rana MM 

PROVIDER: S-EPMC12083590 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature