Childhood Trauma and <i>APOEε4</i> are Associated with Adolescent Brain Function, Posttraumatic Stress, and Alcohol-related Outcomes.

ABSTRACT: Childhood trauma affects neurodevelopment and lifelong risk for posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD). Changes in brain structures and function are observed in young carriers of APOEε4, the genetic factor most associated with Alzheimer's disease. Longitudinal studies of APOEε4, childhood trauma, and neural connectivity in adolescence have not been explored. We studied 837 trauma-exposed participants (53% female) from the Collaborative Study on the Genetics of Alcoholism prospective sample, using latent growth curve models to assess associations of childhood trauma and APOEε4 on repeated measures of frontal alpha EEG coherence (EEGc) throughout adolescence and young adulthood. Young adult AUD and PTSD symptoms were also examined. Results in

SUBMITTER: Neale ZE 

PROVIDER: S-EPMC12083618 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature