Recommendations for the local management of digital ulcers in systemic sclerosis: A report from the World Scleroderma Foundation (WSF) 'Ad hoc committee'.

ABSTRACT:

Introduction

Digital ulcers (DUs) stand out as one of the most prevalent and clinically meaningful manifestations of systemic sclerosis (SSc) and are associated with significant morbidity. While systemic (pharmacological) therapy is currently established as the 'standard of care', effective local ulcer management remains crucial for all cases of DUs. This is particularly true for patients who cannot tolerate systemic treatments or in the case of refractory SSc-DUs. On this background, there is a pressing demand for the formulation of evidence-based guidelines to assist clinicians and patients in navigating the local treatment options for DUs.

Methods

A steering committee of international experts was established by the World Scleorderma Foundation (WSF) Digital Ulcer (DU) ad

SUBMITTER: Campochiaro C 

PROVIDER: S-EPMC12084219 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature