The causal effects of systemic antioxidant capacity on male infertility: A two-sample mendelian randomization analysis.

ABSTRACT: The present research aimed to assess the potential causal relationship between systemic antioxidant capacity and male infertility using a two-sample Mendelian randomization approach. The primary MR analysis utilized the inverse variance weighted (IVW)method, supplemented by complementary analyses including MR-Egger, weighted mode, simple mode, and weighted median methods. For male infertility, the available summarized data were gained from the open database (IEU OPEN GWAS PROJECT), which includes a total of 680 male patients with infertility and 72,799 controls of European population.10 biomarkers related to systemic antioxidant capacity were examined to investigate their potential association with male infertility, including glutathione S-transferase (GST), superoxide dismutase(SOD), glut

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12084361 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature