SARS-CoV-2 induced immune perturbations in infants vary with disease severity and differ from adults' responses.

ABSTRACT: Differences in immune profiles of children and adults with COVID-19 have been previously described. However, no systematic studies have been reported from infants hospitalized with severe disease. We applied a multidimensional approach to decipher the immune responses of SARS-CoV-2 infected infants (n = 26; 10 subacute, 11 moderate and 5 severe disease; median age = 1.6 months) and matched controls (n = 14; median age = 2 months). Single cell (scRNA-seq) profiling of PBMCs revealed substantial alterations in cell composition in SARS-CoV-2 infected infants; with most cell-types switching to an interferon-stimulated gene (ISG^hi) state including: (i) CD14⁺ monocytes co-expressing ISGs and inflammasome-related molecules, (ii) ISG^hi naive CD4⁺ T cells

SUBMITTER: Nehar-Belaid D 

PROVIDER: S-EPMC12084365 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature