Evaluating the causal effects of life-course adiposity on jaw anomalies.

ABSTRACT:

Background

Observational studies indicate that obesity correlates with jaw development and remodeling; however, causality remains unclear. This study aimed to examine the potential causal relationship between life-course adiposity and jaw anomalies.

Methods

Utilizing summary statistics from genome-wide association studies predominantly of European ancestry, we conducted univariable and multivariable Mendelian randomization (MR) to estimate overall and independent effects of six obesity traits (birth weight, childhood body size, childhood body mass index [BMI], adult BMI, adult body fat percentage, and adult waist circumference) on seven jaw anomalies, including bimaxillary hypoplasia, prognathism, retrognathism, and jaw asymmetry. Comprehensive sensitivity analyses verified

SUBMITTER: Chen X 

PROVIDER: S-EPMC12084473 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature