Heat stress induces specific methylation, transcriptomic and metabolic pattern in dairy cows and their female progeny.

ABSTRACT: A heat stress (HS) cattle research design was implemented to study HS effects on the three different "omics features" methylations, gene expressions and metabolic pattern from a direct perspective in pregnant cows and from an indirect time-lagged intergenerational perspective in offspring (the respective F1 and as F1 offspring before calving). In this regard, a total number of 88 German Holstein dairy cows and their 93 female calves were blood sampled for DNA and RNA extraction and for metabolic phenotyping, and allocated to HS and respective control groups (the cows (dams) as well as their calves) according to a temperature-humidity threshold of 60. Separate principal component analyses for all "omics-tiers" revealed clear separations of HS from respective control groups, as well as dam-o

SUBMITTER: Halli K 

PROVIDER: S-EPMC12084553 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature