Prolyl 4-hydroxylase subunit alpha-2 acts as a TRIM21 ubiquitination substrate to promote papillary thyroid cancer progression via the glycolytic pathway.

ABSTRACT: Papillary thyroid cancer (PTC), the predominant thyroid cancer, exhibits different adverse outcomes. However, the underlying molecular mechanisms of PTC remain inadequately elucidated. An integrative analysis of multiple mRNA-seq datasets from Gene Expression Omnibus and The Cancer Genome Atlas reveals a crucial gene, prolyl 4-hydroxylase subunit alpha-2 (P4HA2), implicated in PTC progression. This study explored the expression pattern, functional role, and underlying molecular mechanism of P4HA2 in PTC. P4HA2 expression is significantly upregulated in PTC and correlates with aggressive clinicopathological features and a poor prognosis. P4HA2 knockdown effectively suppresses PTC cell proliferation, migration, and invasion, and induces apoptosis. Conversely, P4HA2 overexpression exerts oppo

SUBMITTER: Wu F 

PROVIDER: S-EPMC12084645 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature