Alternative mRNA splicing in anthracycline-induced cardiomyopathy - a COG-ALTE03N1 report.

ABSTRACT:

Background

Anthracycline-induced cardiomyopathy is a well-established adverse consequence in childhood cancer survivors. Altered mRNA expression in the peripheral blood has been found at the level of genes and pathways among anthracycline-exposed childhood cancer survivors with and without cardiomyopathy. However, the role of aberrant alternative splicing in anthracycline-induced cardiomyopathy remains unexplored. The present study examined if transcript-specific events, due to alternative splicing occur in anthracycline-exposed childhood cancer survivors with and without cardiomyopathy.

Methods

Participants were anthracycline-exposed childhood cancer survivors with cardiomyopathy (cases) matched with anthracycline-exposed childhood cancer survivors without cardiomyopathy (c

SUBMITTER: Singh P 

PROVIDER: S-EPMC12084991 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature