Shared genetic architecture between leukocyte telomere length and Alzheimer's disease.

ABSTRACT:

Background

Epidemiological and clinical studies have reported an association between leukocyte telomere length (LTL) and Alzheimer's disease (AD). However, genetic association between the two phenotypes remains largely unknown. We aimed to elucidate the potential shared genetic architecture between LTL and AD.

Methods

Summary statistics from genome-wide association studies were obtained from large-scale biobank in European-ancestry populations for LTL (N = 472,174) and AD (71,880 cases, 383,378 controls). We examined the global and local genetic correlation between LTL and AD using linkage-disequilibrium score regression and ρ-HESS. We applied the bivariate causal mixture model (MiXeR) to calculate the number of shared genetic causal variants, and the conditional/conjunction

SUBMITTER: Cao Z 

PROVIDER: S-EPMC12085009 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature