Roles of chromosomal and gonadal sex in the fetal and placental responses to maternal food restriction in mice.

ABSTRACT: It is hypothesized that male fetuses are more vulnerable to in utero insults than females due to different growth strategies, and that the placenta contributes to these sex differences. We examined sex differences in the fetal and placental responses to maternal food restriction (∼60% of ad libitum) beginning mid-gestation (Day 11.5). To dissect the roles of chromosomal and gonadal sex, we used the Four Core Genotypes mouse model, which combines deletion of the testis-determining Sry gene from the Y chromosome and autosomal insertion of the Sry gene, such that XX gonadal males and XY gonadal females are produced in addition to XX females and XY males. Food restriction reduced fetal and placental weights but had no effect on the number of viable conceptuses. However, this effect did not dif

SUBMITTER: Hercus JC 

PROVIDER: S-EPMC12085225 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature