DsRNAmax: a multi-target chimeric dsRNA designer for safe and effective crop protection.

ABSTRACT: Crop protection is undergoing significant evolution, transitioning towards sustainable approaches that minimize impacts on the environment and human health. Exogenous application of double-stranded RNA (dsRNA) that silences pest or pathogen genes via RNA interference (RNAi) has promise as a safe and effective next-generation crop protection platform without the need for genetic modification. However, exogenous dsRNA application at scale presents challenges. Specifically, a single dsRNA sequence needs to balance targeting the standing variation in a target pest or pathogen group against the potential for adverse impacts in a vast array of non-target and beneficial organisms at the application site and broader environment. To address these competing demands, we present dsRNAmax (https://gith

SUBMITTER: Fletcher SJ 

PROVIDER: S-EPMC12086532 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature